Collaboration Opportunity

Collaboration Opportunities

MicroBiopharm Japan Co., Ltd. (hereinafter referred to as "MBJ") regards external partnerships as a useful opportunity to generate synergy for more value to all stakeholders in the industry.

Active Collaboration Case with Customers

Case 1:
Contract Manufacturing of Fermentation Products

1) Conclusion of contract manufacturing agreement with a company selling a product obtained by fermentation

2) Further improvement of productivity and quality after start of manufacturing and proposing a better product production method to the customer

Technical Transfer

Partner
  • Disclosing technology
MBJ
  • Making a plan to commercial production

Process ImprovementEstablishment of an efficient production system for target compounds by fermentation technology

Partner
  • Additional information
MBJ
  • Proposal of efficient production system construction

Contract ManufacturingSupplying fermentation products

Partner  
MBJ
  • Contract manufacturing and stable supply

*MBJ has many experiences on contract manufacturing with domestic and overseas companies,
including drug substances/intermediates, food additives, pesticides, and chemical products.

Case 2:
ADC Drug Discovery Service

1) ez-ADiCon™ (ADC conjugation technology based on MBJ's original enzymes) for drug discovery support and sample preparation

2) ez-ADiCon™ available for licensing

Drug Discovery SupportVerification of novel ADC synthesis with MBJ's conjugation technology

Sample preparation

Partner
  • Planning ADC development
  • Providing an antibody
  • Evaluating pharmacological effect
MBJ
  • Verification of ADC synthesis
  • Sample preparation

LicensingProviding ADC conjugation technology

Partner
  • Development of a ADC candidate
  • Clinical study, Launch
MBJ
  • Technology licensing
  • Technology optimization
Case 3:
Enzyme Improvement for Bioconversion

1) Conclusion of contract research agreement on process improvement. Collaborator has a trouble on crystallization step due to by-products

2) Improvement of enzyme to remove side reactions with our technology on contract research

3) Trial manufacturing for practical use

Technology Transfer

Partner
  • Disclosing information
MBJ
  • Showing a successful image
  • Preparing a development plan

Contract ResearchEnzyme improvement

Partner
  • Additional information
MBJ
  • Enzyme improvement
  • Construction of an efficient production system

Practical Application Study

Partner
  • Solving problem based on our products
  • Increasing productivity
MBJ
  • Contract manufacturing
  • Further improvement study

* MBJ has a large number of experiences in contract research and manufacturing
from pharmaceutical and food manufacturers.

Case 4:
Development of New Drugs and Products
-Supplying Microbial Products to Customers-

1) MBJ provides its own extracts of isolated bacteria to partners

2) Partners seek for the case they find substances that can be candidates of pharmaceuticals and new products

3) Based on partners request, MBJ provides the substances produced by microorganisms (the productivity is raised with traditional and genetical strain improvement techniques and the process is established for the commercial production)

Drug Discovery SupportDiscovery of drug and new product candidates from microbial extracts

Partner
  • Assay, evaluation
MBJ
  • Supplying microbial extracts

Contract Development WorkEfficient production of candidate compounds by fermentation technology

Partner
  • Selection of candidate compounds
  • Preclinical and evaluation studies
MBJ
  • Establishment of an efficient production method for lead compounds
  • Supplying samples

Contract ManufacturingClinical trials with the compounds

Partner
  • Clinical trials, sales
MBJ
  • Establishment of manufacturing process (GMP)
  • Supplying target compounds

* MBJ is cooperating with a number of major pharmaceutical and agrochemical manufacturers.

Please don't hesitate to contact us.